Inheritance beyond DNA sequence: news from worms and fishes

Datum

09.05.2019

Zeit

11:00 - 12:00

Sprecher

Eric Miska

Zugehörigkeit

The Gurdon Institute, University of Cambridge, UK

Sprache

en

Hauptthema

Biologie

Host

Mihail Sarov

Beschreibung

Since August Weismann (1834-1914) formulated the distinction between innate and acquired characteristics at the end of the 19th century, the debate relating to the inheritance of acquired traits has raised many controversies in the scientific community. Following convincing arguments against (e.g. William Bateson) this debate was then set aside by the majority of the scientific community. However, a number of epigenetic phenomena involving RNA, histone modification or DNA methylation in many organisms have renewed interest in this area. Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. We recently demonstrated that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many generations in C. elegans. We will discuss evidence for such inheritance in an emerging vertebrate model, the cichlid fish of Malawi.

Letztmalig verändert: 10.05.2019, 00:06:32