Inheritance beyond DNA sequence: news from worms and fishes

Date

May 9, 2019

Time

11:00 AM - 12:00 PM

Speaker

Eric Miska

Affiliation

The Gurdon Institute, University of Cambridge, UK

Language

en

Main Topic

Biologie

Host

Mihail Sarov

Description

Since August Weismann (1834-1914) formulated the distinction between innate and acquired characteristics at the end of the 19th century, the debate relating to the inheritance of acquired traits has raised many controversies in the scientific community. Following convincing arguments against (e.g. William Bateson) this debate was then set aside by the majority of the scientific community. However, a number of epigenetic phenomena involving RNA, histone modification or DNA methylation in many organisms have renewed interest in this area. Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. We recently demonstrated that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many generations in C. elegans. We will discuss evidence for such inheritance in an emerging vertebrate model, the cichlid fish of Malawi.

Last modified: May 10, 2019, 12:06:32 AM