Super-resolution imaging of chromatin in health and disease
- Date
- Jan 30, 2026
- Time
- 11:00 AM - 12:00 PM
- Speaker
- Melike Lakadamyali
- Affiliation
- University of Pennsylvania, Perelman School of Medicine
- Series
- Physics of Life Seminar
- Language
- en
- Main Topic
- Biologie
- Host
- Jan Brugués
- Description
We are pleased to announce an additional PoL Research Seminar with a talk by Melike Lakadamyali from University of Pennsylvania, Perelman School of Medicine.
When? Friday, 30. January 2026, 11:00 am
Where? CRTD auditorium rightAbstract:
Super-resolution microscopy has opened new possibilities for visualizing chromatin architecture in situ at nanoscale resolution. Leveraging quantitative super-resolution imaging, we revealed the heterogeneous nature of nucleosome folding and demonstrated that chromatin structure at both nano- and meso-scales is highly plastic, dynamically remodeling in response to chemical and mechanical cues in health and disease. By combining biologically interpretable feature extraction with machine learning, we further showed that cells can be accurately classified into distinct states based solely on their multi-scale chromatin organization, while also identifying the specific chromatin features that drive classification, thus offering mechanistic insight into cell-state regulation.
- Links
Last modified: Jan 30, 2026, 7:38:53 AM
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- TUD CRTD
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- +49 351 463-40315
- TUD Physics of Life
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- https://physics-of-life.tu-dresden.de
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