Super-resolution imaging of chromatin in health and disease

Datum

30.01.2026

Zeit

11:00 - 12:00

Sprecher

Melike Lakadamyali

Zugehörigkeit

University of Pennsylvania, Perelman School of Medicine

Serie

Physics of Life Seminar

Sprache

en

Hauptthema

Biologie

Host

Jan Brugués

Beschreibung

We are pleased to announce an additional PoL Research Seminar with a talk by Melike Lakadamyali from University of Pennsylvania, Perelman School of Medicine. 

When?  Friday, 30. January 2026, 11:00 am
Where? CRTD auditorium right

Abstract:

Super-resolution microscopy has opened new possibilities for visualizing chromatin architecture in situ at nanoscale resolution. Leveraging quantitative super-resolution imaging, we revealed the heterogeneous nature of nucleosome folding and demonstrated that chromatin structure at both nano- and meso-scales is highly plastic, dynamically remodeling in response to chemical and mechanical cues in health and disease. By combining biologically interpretable feature extraction with machine learning, we further showed that cells can be accurately classified into distinct states based solely on their multi-scale chromatin organization, while also identifying the specific chromatin features that drive classification, thus offering mechanistic insight into cell-state regulation.

Links

• See this event on the Physics of Life website

Letztmalig verändert: 30.01.2026, 07:38:53