CMCB Life Sciences Seminar: Dr. Jirka Peschek, Heidelberg University

Date

Apr 27, 2023

Time

3:00 PM - 4:00 PM

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Willkommen

Other Topics

Willkommen

Description

Host: Titus Franzmann

Title: "Sealing the deal – RNA ligation mechanisms during non-conventional splicing"

Abstract:

Eukaryotic tRNA ligases are an essential component of the cellular tRNA splicing machinery. Intriguingly, two distinct enzymatic strategies have evolved in fungi and higher eukaryotes. In my group we are interested in understanding the mechanisms of tRNA ligases as well as their cellular roles during non-conventional splicing and RNA repair. I will present our latest structural and biochemical insights into the RNA sealing activities of human and fungal tRNA ligases. These findings support our long-term goal to harness RNA processing enzymes as biotechnological tools and therapeutic targets for human disease.

Publications:

Gerber JL, Morales Guzmán SI, Worf L, Hubbe P, Kopp J, Peschek J (2023) Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. bioRxiv. https://doi.org/10.1101/2023.03.30.534986 (https://doi.org/10.1101/2023.03.30.534986)

Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, & Walter P (2021). Protomer alignment modulates specificity of RNA substrate recognition by Ire1. eLife 10:e67425.

Peschek J & Walter P (2019) tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. eLife 8:e44199 (https://tu-dresden.de/cmcb/die-einrichtung/termine/).

Peschek J, Acosta-Alvear D, Mendez AS, Walter P (2015) A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. EMBO Rep. 16(12):1688-98.

Peschek J, Braun N, Rohrberg J, Back KC, Kriehuber T, Kastenmüller A, Weinkauf S, Buchner J (2013) Regulated structural transitions unleash the chaperone activity of αB-crystallin. PNAS 110(40):E3780-9.

Everybody is welcome!

Links

• Termindetails auf den Webseiten der TU Dresden (https://tu-dresden.de)

Last modified: Apr 27, 2023, 7:38:23 AM