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UID:DSC-19637
DTSTART;TZID=Europe/Berlin:20230427T150000
SEQUENCE:1682573903
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20230427T160000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/19637
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:CMCB Life Sciences Seminar: Dr. Jirka Peschek\, Heidelberg Universi
 ty
CLASS:PUBLIC
DESCRIPTION:Speaker: \nInstitute of Speaker: \nTopics:\nWillkommen\n Locati
 on:\n  Name: TUD CRTD ()\n  Street: Fetscherstraße 105\n  City: 01307 Dre
 sden\n  Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82059 \nDescrip
 tion: <p><strong>Host:</strong> Titus Franzmann</p>  <p><strong>Title:</st
 rong> \"Sealing the deal – RNA ligation mechanisms during non-convention
 al splicing\"</p>  <p><strong>Abstract:</strong></p>  <p>Eukaryotic tRNA l
 igases are an essential component of the cellular tRNA splicing machinery.
  Intriguingly\, two distinct enzymatic strategies have evolved in fungi an
 d higher eukaryotes. In my group we are interested in understanding the me
 chanisms of tRNA ligases as well as their cellular roles during non-conven
 tional splicing and RNA repair. I will present our latest structural and b
 iochemical insights into the RNA sealing activities of human and fungal tR
 NA ligases. These findings support our long-term goal to harness RNA proce
 ssing enzymes as biotechnological tools and therapeutic targets for human 
 disease.</p>  <p><strong>Publications:</strong></p>  <p>Gerber JL\, Morale
 s Guzmán SI\, Worf L\, Hubbe P\, Kopp J\, <strong>Peschek J</strong> (202
 3) Structural and mechanistic insights into activation of the human RNA li
 gase RTCB by Archease. bioRxiv. https://doi.org/10.1101/2023.03.30.534986 
 (https://doi.org/10.1101/2023.03.30.534986)</p>  <p>Li W\, Crotty K\, Garr
 ido Ruiz D\, Voorhies M\, Rivera C\, Sil A\, Mullins RD\, Jacobson MP\, <s
 trong>Peschek J</strong>\, &amp\; Walter P (2021). Protomer alignment modu
 lates specificity of RNA substrate recognition by Ire1. eLife 10:e67425.
 </p>  <p><strong>Peschek J</strong> &amp\; Walter P (2019) tRNA ligase str
 ucture reveals kinetic competition between non-conventional mRNA splicing 
 and mRNA decay. eLife 8:e44199 (https://tu-dresden.de/cmcb/die-einrichtung
 /termine/).</p>  <p><strong>Peschek J</strong>\, Acosta-Alvear D\, Mendez 
 AS\, Walter P (2015) A conformational RNA zipper promotes intron ejection 
 during non-conventional XBP1 mRNA splicing. EMBO Rep. 16(12):1688-98.</p> 
  <p><strong>Peschek J</strong>\, Braun N\, Rohrberg J\, Back KC\, Kriehube
 r T\, Kastenmüller A\, Weinkauf S\, Buchner J (2013) Regulated structural
  transitions unleash the chaperone activity of αB-crystallin. PNAS 110(40
 ):E3780-9.</p>  <p><strong>Everybody is welcome!</strong></p>
DTSTAMP:20260521T201541Z
CREATED:20230222T063819Z
LAST-MODIFIED:20230427T053823Z
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