Bi

Mechanical forces and the nucleus: regulation of cell fate and beyond

Date
Sep 10, 2020
Time
11:00 AM - 12:00 PM
Speaker
Sara Wickström
Affiliation
University of Helsinki, Finland
Series
MPI-CBG Thursday Seminar
Language
en
Main Topic
Biologie
Host
Anne Grapin-Botton
Description
Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress, compression, differential tissue rigidity, and strain, to which they respond to by engaging mechanisms of mechanotransduction. These forces function as important morphogenetic ques that are transmitted to the nucleus to alter genetic programs. On the other hand, excessive mechanical stresses have the potential to damage cells and tissues. In my presentation I will discuss our recent research on how mechanical signals are transmitted into the nucleus to coordinate cell fate changes. I will further discuss how dynamic changes in chromatin organization in response to force change the mechanical properties of the nucleus and chromatin to prevent damage, as well how cells can adapt to differential force environments by changing their structure.

Last modified: Sep 11, 2020, 12:10:02 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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