Mechanical forces and the nucleus: regulation of cell fate and beyond

Date

Sep 10, 2020

Time

11:00 AM - 12:00 PM

Speaker

Sara Wickström

Affiliation

University of Helsinki, Finland

Series

MPI-CBG Thursday Seminar

Language

en

Main Topic

Biologie

Host

Anne Grapin-Botton

Description

Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress, compression, differential tissue rigidity, and strain, to which they respond to by engaging mechanisms of mechanotransduction. These forces function as important morphogenetic ques that are transmitted to the nucleus to alter genetic programs. On the other hand, excessive mechanical stresses have the potential to damage cells and tissues. In my presentation I will discuss our recent research on how mechanical signals are transmitted into the nucleus to coordinate cell fate changes. I will further discuss how dynamic changes in chromatin organization in response to force change the mechanical properties of the nucleus and chromatin to prevent damage, as well how cells can adapt to differential force environments by changing their structure.

Last modified: Sep 11, 2020, 12:10:02 AM