Bi

Mechanical forces and the nucleus: regulation of cell fate and beyond

Datum
10.09.2020
Zeit
11:00 - 12:00
Sprecher
Sara Wickström
Zugehörigkeit
University of Helsinki, Finland
Serie
MPI-CBG Thursday Seminar
Sprache
en
Hauptthema
Biologie
Host
Anne Grapin-Botton
Beschreibung
Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress, compression, differential tissue rigidity, and strain, to which they respond to by engaging mechanisms of mechanotransduction. These forces function as important morphogenetic ques that are transmitted to the nucleus to alter genetic programs. On the other hand, excessive mechanical stresses have the potential to damage cells and tissues. In my presentation I will discuss our recent research on how mechanical signals are transmitted into the nucleus to coordinate cell fate changes. I will further discuss how dynamic changes in chromatin organization in response to force change the mechanical properties of the nucleus and chromatin to prevent damage, as well how cells can adapt to differential force environments by changing their structure.

Letztmalig verändert: 11.09.2020, 00:10:02

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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