„The invasion speed of cell migration models with realistic cell cycle time distributions“

Date

Dec 12, 2018

Time

11:30 AM - 12:30 PM

Speaker

Enrico Gavagnin

Affiliation

University of Bath

Series

TUD ZIH Kolloquium

Language

en

Main Topic

Biologie

Other Topics

Biologie, Informatik

Host

Ralph Müller-Pfefferkorn, Zentrum für Informationsdienste und Hochleistungsrechnen

Description

Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show that this assumption is often far from the real cell cycle time distribution (CCTD). In this talk I will  investigate the connection between the CCTD and the speed of the collective cell invasion. I will present a series of stochastic and deterministic age-structured models which can be used to explore this connection from an analytical perspective. The results allow us to determine the range of possible invasion speeds in terms of the average cell proliferation time. Finally, I will discuss potential medical applications of these models to melanoma drug treatment optimisation and other extensions.

Links

• http://tu-dresden.de/veranstaltungen/termin?id=TUD5c068d7aaf8a9

Last modified: Dec 12, 2018, 1:10:00 AM