„The invasion speed of cell migration models with realistic cell cycle time distributions“

Datum

12.12.2018

Zeit

11:30 - 12:30

Sprecher

Enrico Gavagnin

Zugehörigkeit

University of Bath

Serie

TUD ZIH Kolloquium

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Informatik

Host

Ralph Müller-Pfefferkorn, Zentrum für Informationsdienste und Hochleistungsrechnen

Beschreibung

Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show that this assumption is often far from the real cell cycle time distribution (CCTD). In this talk I will  investigate the connection between the CCTD and the speed of the collective cell invasion. I will present a series of stochastic and deterministic age-structured models which can be used to explore this connection from an analytical perspective. The results allow us to determine the range of possible invasion speeds in terms of the average cell proliferation time. Finally, I will discuss potential medical applications of these models to melanoma drug treatment optimisation and other extensions.

Links

• http://tu-dresden.de/veranstaltungen/termin?id=TUD5c068d7aaf8a9

Letztmalig verändert: 12.12.2018, 01:10:00