Bi

DynAPs - Liquid-like organelles at the root of motile ciliopathy

Date
Nov 7, 2019
Time
11:00 AM - 12:00 PM
Speaker
John Wallingford
Affiliation
University of Texas at Austin, USA
Language
en
Main Topic
Biologie
Host
Jacqueline Tabler
Description
Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients harbor mutations in the dynein motors that drive cilia beating, the disease also results from mutations in so-called dynein axonemal assembly factors (DNAAFs) that act in the cytoplasm. Here, I will describe the discovery of DynAPs novel liquid-like organelles that compartmentalize axonemal dyneins and their assembly factors as well as recent interactive-mapping efforts to understand DynAP assembly and function. These findings provide a unifying cell biological framework for a poorly understood class of human disease genes and add motile ciliopathy to the growing roster of human diseases associated with disrupted biological phase separation.

Last modified: Oct 20, 2019, 12:09:26 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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