DynAPs - Liquid-like organelles at the root of motile ciliopathy

Datum

07.11.2019

Zeit

11:00 - 12:00

Sprecher

John Wallingford

Zugehörigkeit

University of Texas at Austin, USA

Sprache

en

Hauptthema

Biologie

Host

Jacqueline Tabler

Beschreibung

Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients harbor mutations in the dynein motors that drive cilia beating, the disease also results from mutations in so-called dynein axonemal assembly factors (DNAAFs) that act in the cytoplasm. Here, I will describe the discovery of DynAPs novel liquid-like organelles that compartmentalize axonemal dyneins and their assembly factors as well as recent interactive-mapping efforts to understand DynAP assembly and function. These findings provide a unifying cell biological framework for a poorly understood class of human disease genes and add motile ciliopathy to the growing roster of human diseases associated with disrupted biological phase separation.

Letztmalig verändert: 18.10.2019, 00:09:26