Long-term consequences on the CNS after immune stimulation

Date

Apr 22, 2016

Time

11:00 AM - 12:00 PM

Speaker

Professor Martin Korte

Affiliation

Zoological Institute Div. Cellular Neurobiology TU Braunschweig

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Gerd Kempermann

Description

About the research of Prof. Korte:We study the cellular mechanism of learning, memory and forgetting. We are interested in how memories are formed and consolidated and in addition we study the cellular mechanisms of the onset and progression of neurodegenerative disease, like Alzheimer’s disesase. Synaptic plasticity is the ability of neurons to adjust the strength and the number of synapses due to changes in neuronal activity and it is believed that these changes are necessary for information storage. We found evidence, that the activation of the peripheral immune system and the activation of the immune system in the brain decreases the ability of neurons to be plastic. Infection of the CNS of viral or bacterial pathogens activated the immune system of the brain, the microglia cells. There is even evidence that infection the periphery can affect microglia cell. During ageing the activation of microglia cells can become maladaptive in a sense that it harms and damages neurons via the initiation of events that leads to the production of oxygen and NO radicals.Publications:(1) Sajikumar S, Morris RG, Korte M (2014) Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture. PNAS 111(33): 12117-21.(2) Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker, A, Griep, A, Axt, D, Remus, A, Tzeng, TC, Gelpi, E, Halle, A, Korte, M, Latz, E, and Golenbock, DT 2013.NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493:674-8(3) Zagrebelsky M, Schweigreiter R, Bandtlow CE, Schwab ME, Korte M (2010) Nogo-A stabilizes the architecture of hippocampal neurons. J Neurosci 30:13220-13234.(4) Minichiello L, Calella A, Medina D, Bonhoeffer T, Klein R, Korte M (2002) Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation. Neuron 36:121. (5) Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T (1995) Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. PNAS 92:8856-8860.

Links

• to announcement of the organizer

Last modified: Apr 22, 2016, 9:56:04 AM