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UID:DSC-11185
DTSTART;TZID=Europe/Berlin:20160422T110000
SEQUENCE:1461311764
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20160422T120000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/11185
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Korte: Long-term consequences on the CNS after immune stimulation
CLASS:PUBLIC
DESCRIPTION:Speaker: Professor Martin Korte\nInstitute of Speaker: Zoologic
 al Institute Div. Cellular Neurobiology TU Braunschweig\nTopics:\nBiologie
 \, Medizin\n Location:\n  Name: TUD CRTD (CRTD\, Auditorium left)\n  Stree
 t: Fetscherstraße 105\n  City: 01307 Dresden\n  Phone: +49 (0)351 458 820
 52\n  Fax: +49 (0)351 458 82059 \nDescription: About the research of Prof.
  Korte:We study the cellular mechanism of learning\, memory and forgetting
 . We are interested in how memories are formed and consolidated and in add
 ition we study the cellular mechanisms of the onset and progression of neu
 rodegenerative disease\, like Alzheimer’s disesase. Synaptic plasticity 
 is the ability of neurons to adjust the strength and the number of synapse
 s due to changes in neuronal activity and it is believed that these change
 s are necessary for information storage. We found evidence\, that the acti
 vation of the peripheral immune system and the activation of the immune sy
 stem in the brain decreases the ability of neurons to be plastic. Infectio
 n of the CNS of viral or bacterial pathogens activated the immune system o
 f the brain\, the microglia cells. There is even evidence that infection t
 he periphery can affect microglia cell. During ageing the activation of mi
 croglia cells can become maladaptive in a sense that it harms and damages 
 neurons via the initiation of events that leads to the production of oxyge
 n and NO radicals.Publications:(1) Sajikumar S\, Morris RG\, Korte M (2014
 ) Competition between recently potentiated synaptic inputs reveals a winne
 r-take-all phase of synaptic tagging and capture. PNAS  111(33): 12117-21.
 (2) Heneka MT\, Kummer MP\, Stutz A\, Delekate A\, Schwartz S\, Vieira-Sae
 cker\, A\, Griep\, A\, Axt\, D\, Remus\, A\, Tzeng\, TC\, Gelpi\, E\, Hall
 e\, A\, Korte\, M\, Latz\, E\, and Golenbock\, DT 2013.NLRP3 is activated 
 in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Natur
 e 493:674-8(3) Zagrebelsky M\, Schweigreiter R\, Bandtlow CE\, Schwab ME\,
  Korte M (2010) Nogo-A stabilizes the architecture of hippocampal neurons.
  J Neurosci 30:13220-13234.(4) Minichiello L\, Calella A\, Medina D\, Bonh
 oeffer T\, Klein R\, Korte M (2002) Mechanism of TrkB-Mediated Hippocampal
  Long-Term Potentiation. Neuron 36:121. (5) Korte M\, Carroll P\, Wolf E\,
  Brem G\, Thoenen H\, Bonhoeffer T (1995) Hippocampal long-term potentiati
 on is impaired in mice lacking brain-derived neurotrophic factor. PNAS 92:
 8856-8860.
DTSTAMP:20260425T052420Z
CREATED:20160419T080349Z
LAST-MODIFIED:20160422T075604Z
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