InBi

ZIH-Kolloquium: Characterising the evolutionary modes of cancer and normal tissue

Datum
27.02.2019 
Zeit
11:30 Uhr - 12:30 Uhr 
Sprecher
Robert John Noble 
Institut
ETH Zürich 
Teil der Serie
TUD ZIH Kolloquium 
Sprache
en 
Hauptthema
Informatik: Allgemein
Subthemen
Biologie: Allgemein
Zusammenfassung

"Characterising the evolutionary modes of cancer and normal tissue"

The nature of evolution within normal and neoplastic tissue is a subject of debate. I will present a highly flexible computational model that allows evolutionary dynamics resulting from diverse spatial structures to be compared in a single framework. Combining stochastic simulations with mathematical analysis, I will explain how tissue architecture governs the potential for subclonal expansion, the prevalence of selective sweeps, and spatial patterns of genetic heterogeneity. I will describe the conditions under which genetic diversity is most predictive of tumour progression, and I will discuss applications in optimising treatment protocols and understanding cancer risk variation. These findings help explain the observed multiformity of cancer and normal tissue evolution and contribute to establishing a theoretical foundation for predictive oncology.

 

Letzte Aktualisierung: 27.02.2019 00:07.

Vortragsort 

TUD Informatik - APB (1096) 
Nöthnitzer Straße 46
01069 Dresden
Homepage
https://navigator.tu-dresden.de/etplan/apb/00 

Veranstalter 

Center for Information Services and High Performance Computing (TUD ZIH)
Zellescher Weg 12-14
01069 Dresden
Telefon
+49 351 463-35450 
Fax
+49 351 463-37773 
E-Mail
Center for Information Services and High Performance Computing (TUD ZIH) 
Homepage
http://tu-dresden.de/zih 
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