BiMe

Novel mechanisms of neurogenesis and neuronal repair

Datum
31.01.2019 
Zeit
16:00 Uhr - 17:00 Uhr 
Sprecher
Prof. Magdalena Götz 
Institut
Institute for Stem Cell Research, Helmholtz Center Munich and Biomedical Center, University of Munich, Germany 
Teil der Serie
BIOTEC Green Seminar 
Sprache
en 
Hauptthema
Biologie: Allgemein
Subthemen
Medizin: Regeneration
Ansprechpartner
CMCB Master students (Elena Tonchevska) 
Zusammenfassung

AbstractWe study the mechanisms of neurogenesis in order to implement them for neuronal repair. I will present unpublished work about novel molecular mechanisms important for neurogenesis in the developing murine cerebral cortex and will then turn to using these for direct neuronal reprogramming after traumatic injury of the adult murine cerebral cortex in vivo. I will discuss different viral vector approaches and up-date on a recent breakthrough in direct glia-to-neuron reprogramming achieving high efficiency and mature neuronal subtypes sending out long range projections. I will close by discussing the integration of replaced neurons into the circuitry of the adult murine cerebral cortex, that normally does not integrate new neurons at adult stages and present unpublished data about the mechanisms regulating this integration. Taken together, our knowledge about basic mechanisms of neurogenesis allowed making great strides towards neuronal repair.
5 most recent papersMalatesta et al., 2000Heins et al., 2002 Stahl et al., 2013 Sirko et al., 2013 Falkner, Grade et al., 2016

 

Letzte Aktualisierung: 31.01.2019 00:08.

Vortragsort 

DFG Center for Regenerative Therapies Dresden (CRTD, auditorium left) 
Fetscherstraße 105
01307 Dresden
Telefon
+49 (0)351 458 82064 
Fax
+49 (0)351 458 82059  
E-Mail
DFG Center for Regenerative Therapies Dresden 
Homepage
http://www.crt-dresden.de 

Veranstalter 

DFG Center for Regenerative Therapies Dresden (CRTD)
Fetscherstraße 105
01307 Dresden
Telefon
+49 (0)351 458 82064 
Fax
+49 (0)351 458 82059 
E-Mail
DFG Center for Regenerative Therapies Dresden (CRTD) 
Homepage
http://www.crt-dresden.de 
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