Bi

Precision and plasticity in animal transcription

Datum
23.05.2019 
Zeit
11:00 Uhr - 12:00 Uhr 
Sprecher
Angela DePace 
Institut
Harvard Medical School, Boston, USA 
Teil der Serie
MPI-CBG Thursday Seminar 
Sprache
en 
Hauptthema
Biologie: Zellbiologie (incl. Molekulare), Entwicklungsbiologie
Ansprechpartner
Predocs/Celina Love 
Zusammenfassung

The regulatory DNA that controls transcription harbors natural sequence variants at multiple DNA length scales, from single nucleotide polymorphisms to large scale structural variants. Given that changes in gene regulation are critical in development, disease and evolution, a central challenge is to understand how sequence variants at all of these scales impact proximal molecular phenotypes and downstream organismal phenotypes. I will present our work probing the molecular mechanisms that govern transcription in the developing Drosophila embryo, with a view to understanding how regulatory DNA can drive precise gene expression patterns while the underlying sequence is quite plastic. I will discuss examples at different levels of complexity, from single enhancers to entire developmental loci, and emphasize how coupling quantitative measurements to computational models can decipher underlying principles of transcription.

 

Letzte Aktualisierung: 24.04.2019 00:07.

Vortragsort 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half)) 
Pfotenhauerstraße 108
01307 Dresden
Telefon
+49 351 210-0 
Fax
+49 351 210-2000 
E-Mail
Max Planck Institute of Molecular Cell Biology and Genetics 
Homepage
http://www.mpi-cbg.de 

Veranstalter 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Pfotenhauerstraße 108
01307 Dresden
Telefon
+49 351 210-0 
Fax
+49 351 210-2000 
E-Mail
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) 
Homepage
http://www.mpi-cbg.de 
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