Bi

Sex differences in organ plasticity

Datum
21.03.2019 
Zeit
11:00 Uhr - 12:00 Uhr 
Sprecher
Irene Miguel-Aliaga 
Institut
MRC London Institute of Medical Sciences, Imperial College London, London, UK 
Teil der Serie
MPI-CBG Thursday Seminar 
Sprache
en 
Hauptthema
Biologie: Zellbiologie (incl. Molekulare), Entwicklungsbiologie
Ansprechpartner
Jochen Rink 
Zusammenfassung

Internal organs constantly exchange signals, and can respond with profound anatomical and functional transformations, even in fully developed organisms. Such organ plasticity results from a need to integrate both environmental information and internal state, and is key to maintaining homeostasis and adapting to challenges. We seek to identify the mechanisms by which organs sense and respond to change: the molecules, cellular events and physiological adaptations involved. Some of our recent work has explored the physiological plasticity of the intestinal epithelium using Drosophila and mice, focusing on both stem cells and one their progeny: the digestive/absorptive enterocytes. Our work has revealed unexpected sexual dimorphisms, as well as intestinal contributions to reproductive success. I will discuss some of this work, and will likely present unpublished findings on 1) new hormonal and neuronal mechanisms by which gonads make gut cells sexually dimorphic for “selfish” reasons, and/or 2) a novel intestinal micronutrient sensor that controls systemic food intake and growth rate by activating TOR signalling.

 

Letzte Aktualisierung: 16.02.2019 00:07.

Vortragsort 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half)) 
Pfotenhauerstraße 108
01307 Dresden
Telefon
+49 351 210-0 
Fax
+49 351 210-2000 
E-Mail
Max Planck Institute of Molecular Cell Biology and Genetics 
Homepage
http://www.mpi-cbg.de 

Veranstalter 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Pfotenhauerstraße 108
01307 Dresden
Telefon
+49 351 210-0 
Fax
+49 351 210-2000 
E-Mail
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) 
Homepage
http://www.mpi-cbg.de 
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