Bi

Visualizing pattern formation in the early Drosophila embryo

Datum
28.02.2019 
Zeit
11:00 Uhr - 12:00 Uhr 
Sprecher
Naama Barkai  
Institut
Weizmann Institute of Science, Rehovot, Israel 
Teil der Serie
MPI-CBG Thursday Seminar 
Sprache
en 
Hauptthema
Biologie: Zellbiologie (incl. Molekulare), Entwicklungsbiologie
Ansprechpartner
Marino Zerial 
Zusammenfassung

In the early Drosophila embryo, generation of a pattern is challenged by the diffusible extracellular milieu and the rapid nuclear divisions. To understand how a sharp gradient is formed within this dynamic environment, we followed the formation of pattern in live embryos. We show that a sharp gradient is formed through diffusion-based morphogen shuttling, a model which we previously predicted and supported based on its robustness, namely its ability to buffer environmental or genetic variations. When shuttling is perturbed through specific mutations, the activation peak flattens and gastrulation becomes aberrant. Finally, we show that nuclear re-entry of fate-determining factor at each cycle further refines the signaling output, suggesting a new time-dependent mechanism for pattern refinement. We conclude that diffusion-based ligand shuttling, coupled with dynamic readout, establishes a refined pattern within the diffusible environment of early embryos.

 

Letzte Aktualisierung: 01.03.2019 00:07.

Vortragsort 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half)) 
Pfotenhauerstraße 108
01307 Dresden
Telefon
+49 351 210-0 
Fax
+49 351 210-2000 
E-Mail
Max Planck Institute of Molecular Cell Biology and Genetics 
Homepage
http://www.mpi-cbg.de 

Veranstalter 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Pfotenhauerstraße 108
01307 Dresden
Telefon
+49 351 210-0 
Fax
+49 351 210-2000 
E-Mail
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) 
Homepage
http://www.mpi-cbg.de 
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