BiMe

RNA Biology and its link to human diseases

date
28.03.2019 
time
04:00 PM - 05:00 PM 
speaker
Prof. Utz Fischer 
affiliation
University of Würzburg, Biocenter 
part of series
BIOTEC Green Seminar 
language
en 
main topic
Biology: general
subtopics
Medicine: Regeneration
host
Prof. Rolf Jessberger (Institute of Physiological Chemistry) 
abstract

AbstractThe generation of messenger RNAs (mRNAs) and their translation into proteins depends on the elaborate interplay of a numerous trans-acting factors. These factors are often organized in macromolecular machines, which enable all steps in mRNA metabolism and timely coordinate their progression. The Fischer group studies the functional dynamics of key macromolecular machines acting on RNA using a combination of biochemical, structural and systems biology approaches. RNA-related pathways have been linked to a broad spectrum of human diseases. By combining basic RNA research with biomedical approaches we investigate how these pathways and networks are changed in different disease settings.
PapersImpaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation AB Prusty, R Meduri, BK Prusty, J Vanselow, A Schlosser, U Fischer J Cell Biol 216 (8), 2391-2407 (2017)
Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization Neuenkrichen, N., Englbrecht, C., Ohmer, J., Ziegenhals, T., Chari, A., and Fischer, U. EMBO Journal 34(14):1925-41 (2015)
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Stoll G, et al., Nature Neuroscience 16: 1228-1237 (2013)
Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2 Dill H, Linder B, Fehr A, Fischer U Genes & Development 26(1):25-30 (2012)
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs Chari A, Golas M, Neuenkirchen N, Klingenhäger M, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U Cell 135:497-509 (2008)

 

Last update: 20.03.2019 00:09.

venue 

DFG Center for Regenerative Therapies Dresden (CRTD, ground floor, auditorium left) 
Fetscherstraße 105
01307 Dresden
telefon
+49 (0)351 458 82064 
fax
+49 (0)351 458 82059  
e-mail
DFG Center for Regenerative Therapies Dresden 
homepage
http://www.crt-dresden.de 

organizer 

DFG Center for Regenerative Therapies Dresden (CRTD)
Fetscherstraße 105
01307 Dresden
telefon
+49 (0)351 458 82064 
fax
+49 (0)351 458 82059 
e-mail
DFG Center for Regenerative Therapies Dresden (CRTD) 
homepage
http://www.crt-dresden.de 
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