MePh

FWP Institutskolloquium "AY27 cells / Fischer Rats - an orthotopic, immunocompetent bladder carcinoma model"

date
22.03.2019 
time
01:00 PM - 02:00 PM 
speaker
Prof. Dr. rer. nat. habil. Jochen Neuhaus,Universität Leipzig, Klinik und Poliklinik für Urologie,Leiter des Forschungslabors,Gastprofessor an der "Shanghai University of Medicine and Health Sciences" 
language
en 
main topic
Medicine 
subtopics
Physics: Theoretical Physics, Quantum Physics, Nuclear and Particle Physics, Atomic Physics
host
Prof. Dr. P. Brust, p.brust@hzdr.de 
abstract

Bladder cancer is the fifth leading cancer in Germany. About 30% of the cases are muscle invasive (MIBC) at first diagnosis, requiring radical cystectomy. The novel photosensitizer Tetrahydroporphyrin-Tetratosylate (THPTS) is excitable at near-infrared wavelength of 760nm) and may thus be suitable for Photodynamic Therapy (PDT) of MIBC up to 15 mm thickness. We tested the tumoricidal effect of THPTS-PDT in an orthotopic animal model, and explored cellular mechanisms of action in cultured cells. Single PDT of invasive bladder cancer led to a significant reduction of tumor size and pT-grade at 14 days after treatment. Apoptosis was the predominant modality of cell death. In addition, we found an immunostimulatory effect of THPTS-PDT in the rat model.

 

Last update: 20.03.2019 00:09.

venue 

Helmholtz-Zentrum Dresden-Rossendorf (L9.3/216 - Bibliothek) 
Bautzner Landstraße 400
01328 Dresden
e-mail
Helmholtz-Zentrum Dresden-Rossendorf 
homepage
http://www.hzdr.de 

organizer 

Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
Bautzner Landstraße 400
01328 Dresden
e-mail
Helmholtz-Zentrum Dresden-Rossendorf (HZDR) 
homepage
http://www.hzdr.de 
Scan this code with your smartphone and get directly this event in your calendar. Increase the image size by clicking on the QR-Code if you have problems to scan it.