BiMe

Precise genome engineering to empower drug discovery

date
18.01.2019 
time
03:00 PM - 04:00 PM 
speaker
Marcello Maresca 
affiliation
AstraZeneca Research Gothenburg, Sweden 
part of series
BIOTEC Green Seminar 
language
en 
main topic
Biology: general
subtopics
Medicine: Regeneration
host
Prof. Dr. Francis Stewart 
abstract

InformationGene and base editing hold great promises in the prevention and treatment of genetic diseases. Predicting the on-target and off-target activities of Cas9/CRISPR and Base Editors is an essential requirement for a safe and efficacious treatment. Recent progress shows how the analysis and modulation of DNA repair pathway can be applied to predict base and genome editing outcomes.
Taheri-Ghahfarokhi, Amir, et al. Decoding non-random mutational signatures at Cas9 targeted sites. Nucleic acids research 46.16 (2018): 8417-8434.Akcakaya, Pinar, et al. In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature 561.7723 (2018): 416.Wienert, Beeke, et al. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. bioRxiv (2018): 469635.

 

Last update: 18.01.2019 00:09.

venue 

DFG Center for Regenerative Therapies Dresden (CRTD, auditorium left) 
Fetscherstraße 105
01307 Dresden
telefon
+49 (0)351 458 82064 
fax
+49 (0)351 458 82059  
e-mail
DFG Center for Regenerative Therapies Dresden 
homepage
http://www.crt-dresden.de 

organizer 

Biotechnologisches Zentrum der TU Dresden (BIOTEC)
Tatzberg 47-49
01307 Dresden
telefon
+49 (0)351 458 82064 
fax
+49 (0)351 458 82059 
e-mail
Biotechnologisches Zentrum der TU Dresden (BIOTEC) 
homepage
http://www.biotec.tu-dresden.de 
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