BiCo

„The invasion speed of cell migration models with realistic cell cycle time distributions“

date
12.12.2018 
time
11:30 AM - 12:30 PM 
speaker
Enrico Gavagnin 
affiliation
University of Bath 
part of series
TUD ZIH Colloquium 
language
en 
main topic
Biology: general
subtopics
Computer Science: general
host
Ralph Müller-Pfefferkorn, Zentrum für Informationsdienste und Hochleistungsrechnen 
abstract

Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show that this assumption is often far from the real cell cycle time distribution (CCTD). In this talk I will  investigate the connection between the CCTD and the speed of the collective cell invasion. I will present a series of stochastic and deterministic age-structured models which can be used to explore this connection from an analytical perspective. The results allow us to determine the range of possible invasion speeds in terms of the average cell proliferation time. Finally, I will discuss potential medical applications of these models to melanoma drug treatment optimisation and other extensions.

 

Last update: 12.12.2018 00:10.

venue 

TUD Informatik - APB (APB 1096) 
Nöthnitzer Straße 46
01069 Dresden
homepage
https://navigator.tu-dresden.de/etplan/apb/00 

organizer 

Center for Information Services and High Performance Computing (TUD ZIH)
Zellescher Weg 12-14
01069 Dresden
telefon
+49 351 463-35450 
fax
+49 351 463-37773 
e-mail
Center for Information Services and High Performance Computing (TUD ZIH) 
homepage
http://tu-dresden.de/zih 
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