Bi

Sex differences in organ plasticity

date
21.03.2019 
time
11:00 AM - 12:00 PM 
speaker
Irene Miguel-Aliaga 
affiliation
MRC London Institute of Medical Sciences, Imperial College London, London, UK 
part of series
MPI-CBG Thursday Seminar 
language
en 
main topic
Biology: Cell Biology (incl. Molecular, Structural), Developmental Biology
host
Jochen Rink 
abstract

Internal organs constantly exchange signals, and can respond with profound anatomical and functional transformations, even in fully developed organisms. Such organ plasticity results from a need to integrate both environmental information and internal state, and is key to maintaining homeostasis and adapting to challenges. We seek to identify the mechanisms by which organs sense and respond to change: the molecules, cellular events and physiological adaptations involved. Some of our recent work has explored the physiological plasticity of the intestinal epithelium using Drosophila and mice, focusing on both stem cells and one their progeny: the digestive/absorptive enterocytes. Our work has revealed unexpected sexual dimorphisms, as well as intestinal contributions to reproductive success. I will discuss some of this work, and will likely present unpublished findings on 1) new hormonal and neuronal mechanisms by which gonads make gut cells sexually dimorphic for “selfish” reasons, and/or 2) a novel intestinal micronutrient sensor that controls systemic food intake and growth rate by activating TOR signalling.

 

Last update: 20.03.2019 00:09.

venue 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half)) 
Pfotenhauerstraße 108
01307 Dresden
telefon
+49 351 210-0 
fax
+49 351 210-2000 
e-mail
Max Planck Institute of Molecular Cell Biology and Genetics 
homepage
http://www.mpi-cbg.de 

organizer 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Pfotenhauerstraße 108
01307 Dresden
telefon
+49 351 210-0 
fax
+49 351 210-2000 
e-mail
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) 
homepage
http://www.mpi-cbg.de 
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