Bi

Long-range Gene Regulation During Vertebrate Development and Evolution

date
24.01.2019 
time
11:00 AM - 12:00 PM 
speaker
Denis Duboule 
affiliation
School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Department of Genetics and Evolution, University of Geneva, Switzerland and Collège de France, Paris  
part of series
MPI-CBG Thursday Seminar 
language
en 
main topic
Biology: Cell Biology (incl. Molecular, Structural), Developmental Biology
host
Nadine Vastenhouw 
abstract

During vertebrate development, clustered Hox genes are controlled by enhancers acting over very long distances and localized within two distinct Topologically Associating Domains (TADs) flanking the genomic cluster. In this talk I will first introduce the experimental system and then discuss two related issues concerned with this complex bimodal regulatory strategy. The first question has to do with the mechanism underlying the boundary effect, which prevents the TADs to interact either with one another, or with target genes located on either side of this boundary. The second point is concerned with the biological relevance of this boundary, i.e. its relevance during development and its function in protecting anterior structures from the dominant effect of posterior genes.

 

Last update: 21.01.2019 00:08.

venue 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half)) 
Pfotenhauerstraße 108
01307 Dresden
telefon
+49 351 210-0 
fax
+49 351 210-2000 
e-mail
Max Planck Institute of Molecular Cell Biology and Genetics 
homepage
http://www.mpi-cbg.de 

organizer 

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Pfotenhauerstraße 108
01307 Dresden
telefon
+49 351 210-0 
fax
+49 351 210-2000 
e-mail
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) 
homepage
http://www.mpi-cbg.de 
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