Müller Cell Gliosis as Pathogenic Factor of Retinal Edema and Neurodegeneration

Date

Oct 9, 2015

Time

11:00 AM - 12:00 PM

Speaker

Prof. Andreas Bringmann Department of Ophthalmology and Eye Hospital, Medical Faculty, University of Leipzig

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Prof. Michael Brand

Description

About the research of Andreas Bringmann: The topics of the research are the contribution of Müller cell gliosis to the development of retinal edema and neurodegeneration and functional alterations of the retinal pigment epithelium which may contribute to the development of AMD. Previous research involved studies regarding the functional roles of glial potassium and water channels in the normal and diseased retina, the mechanisms of cellular swelling and the receptor-mediated regulation of the Müller and neuronal cell volume, the role of purinergic receptors in the retinal development and under pathological conditions, and the functional roles of cytokines in the retinal pigment epithelium. Publications: (1) Uckermann O, Vargová L, Ulbricht E, Klaus C, Weick M, Rillich K, Wiedemann P, Reichenbach A, Syková E, Bringmann A. Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea-pig retina. J Neurosci 2004;24:10149-10158. (2) Pannicke T, Iandiev I, Uckermann O, Biedermann B, Kutzera F, Wiedemann P, Wolburg H, Reichenbach A, Bringmann A. A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol Cell Neurosci 2004;26:493-502. (3) Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, Osborne NN, Reichenbach A. Müller cells in the healthy and diseased retina. Prog Retin Eye Res 2006;25:397-424. (4) Bringmann A, Iandiev I, Pannicke T, Wurm A, Hollborn M, Wiedemann P, Osborne NN, Reichenbach A. Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res 2009;28:423-451. (5) Linnertz R, Wurm A, Pannicke T, Krügel K, Hollborn M, Härtig W, Iandiev I, Wiedemann P, Reichenbach A, Bringmann A. Activation of voltage-gated Na+ and Ca2+ channels is required for vesicular release of glutamate from retinal glial cells implicated in cell volume regulation. Neuroscience 2011;188:23-34. doi: 10.1016/j.neuroscience.2011.04.058.

Links

• to announcement of the organizer

Last modified: Oct 5, 2015, 9:51:29 AM