Human pluripotent stem cells: a new tool to understand and treat retinal diseases

Date

Apr 9, 2015

Time

4:00 PM - 5:00 PM

Speaker

Dr. Olivier Goureau, Research Director at INSERM Laboratory of Cellular and Molecular Pathophysiology of the Retina U592, "INSERM", Paris, France

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Mike Karl

Description

Information about the research of Dr. Goureau: Our research group aims at understanding retinal differentiation mechanisms and at participating in cell therapy by developing new approaches based on retinal cell regeneration. Our main research fields include the use of human induced pluripotent stem (iPS) cells in cell-based rescue or replacement strategies and in human retinal disease modeling. Our objectives are: i) the development of innovative and robust protocols allowing the differentiation of human iPS cells into different retinal cell types (retinal ganglion cells, photoreceptors and RPE cells) and the ii) derivation of iPS cells from patients affected by specific inherited retinal dystrophies to understand retinal pathological mechanisms and to further develop large-scale drug screening. Selected publications: From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel JA, Monville C, Goureau O. Proc Natl Acad Sci U S A. 2014 Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. Orieux G, Picault L, Slembrouck A, Roger JE, Guillonneau X, Sahel JA, Saule S, McPherson JP, Goureau O. J Neurosci. 2014 Ciliary neurotrophic factor promotes muller glia differentiation from the postnatal retinal progenitor pool. Goureau O, Rhee KD, Yang XJ. Dev Neurosci. 2004 Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy. Sennlaub F, Courtois Y, Goureau O. J Clin Invest. 2001 Mar;107(6):717-25. Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation. Goureau O, Lepoivre M, Becquet F, Courtois Y. Proc Natl Acad Sci U S A. 1993

Links

• to announcement of the organizer

Last modified: Apr 9, 2015, 9:39:57 AM