Biological barriers and the next wave of pharmaceutical innovation

Date

Apr 8, 2015

Time

11:00 AM - 12:00 PM

Speaker

Paul A. Burke

Affiliation

Burke Bioventures LLC, Cambridge, MA, USA

Language

en

Main Topic

Biologie

Other Topics

Biologie

Host

Marino Zerial

Description

New biology—ranging from advances in the understanding of the role of RNA to new approaches to genome editing—presents an explosion of opportunity for therapeutic intervention. Realizing this potential involves traversing biological barriers at the cellular, tissue, and organismal levels. Successes to date include those based on RNAi, targeting, and intracellular delivery of peptides. Though significant, these illustrate the complexity of the challenge biological barriers pose, and the need to move from biologically inspired to “biologically informed” delivery systems. Illustrations for integrating more sophisticated biological techniques include advanced imaging, molecular profiling, and pharmacological tools, in addition to the use of engineered tissue and animal models. Interdisciplinary approaches based on the nexus of advanced biological tools and molecular engineering comprise a new frontier of exploration with unprecedented potential for positive impact to human health.

Last modified: Apr 9, 2015, 9:39:37 AM