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BEGIN:VEVENT
UID:DSC-22853
DTSTART;TZID=Europe/Berlin:20260521T150000
SEQUENCE:1777613991
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260521T160000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/22853
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Lerchbaumer: Using targeted manipulation of cell adhesion to study 
 tissue properties during morphogenesis
CLASS:PUBLIC
DESCRIPTION:Speaker: Gerald Lerchbaumer\nInstitute of Speaker: University o
 f Toronto\, Canada\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Ga
 lleria II (VC))\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n
   Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Cell adhesio
 n is essential for shaping tissues during animal development\, yet how adh
 esion is tuned to support different morphogenetic movements remains unclea
 r. We used optogenetics in the Drosophila embryo to address this question 
 by enhancing clustering of E-cadherin\, a core component of adherens junct
 ions. Increasing E-cadherin clustering enriches E-cadherin at junctions an
 d reduces its mobility\, consistent with enhanced adhesion strength. This 
 approach allows targeted manipulation of cellular adhesive properties in v
 ivo and makes it possible to address questions that were previously diffic
 ult to test directly. By analyzing animal development while increasing cel
 l adhesion throughout the epithelial tissue\, we found that this causes a 
 strong reduction in cell rearrangements during epithelial morphogenesis an
 d disrupts convergent extension of the embryonic axis. To further understa
 nd these effects\, we adapted a vertex model to include adhesion-dependent
  friction between cells. The model predicts that stronger adhesion increas
 es resistance to neighbor exchange and thereby limits tissue remodeling. T
 o test this idea\, we analyzed different morphogenetic movements in the fl
 y and their dependence on cell adhesion. We found that enhanced E-cadherin
  clustering strongly slows morphogenetic processes that depend on both cel
 l shape change and cell rearrangement\, while movements that rely primaril
 y on apical constriction can still proceed. Together\, these findings sugg
 est that E-cadherin clustering is an important regulator of tissue mechani
 cs and that tuning adhesion is critical for morphogenetic events that requ
 ire dynamic cell-cell rearrangements
DTSTAMP:20260501T184312Z
CREATED:20260422T053550Z
LAST-MODIFIED:20260501T053951Z
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