BEGIN:VCALENDAR VERSION:2.0 PRODID:www.dresden-science-calendar.de METHOD:PUBLISH CALSCALE:GREGORIAN X-MICROSOFT-CALSCALE:GREGORIAN X-WR-TIMEZONE:Europe/Berlin BEGIN:VTIMEZONE TZID:Europe/Berlin X-LIC-LOCATION:Europe/Berlin BEGIN:DAYLIGHT TZNAME:CEST TZOFFSETFROM:+0100 TZOFFSETTO:+0200 DTSTART:19810329T030000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU END:DAYLIGHT BEGIN:STANDARD TZNAME:CET TZOFFSETFROM:+0200 TZOFFSETTO:+0100 DTSTART:19961027T030000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT UID:DSC-22755 DTSTART;TZID=Europe/Berlin:20260325T150000 SEQUENCE:1774420536 TRANSP:OPAQUE DTEND;TZID=Europe/Berlin:20260325T163000 URL:https://www.dresden-science-calendar.de/calendar/en/detail/22755 LOCATION:TUD Andreas-Pfitzmann-Bau\, Nöthnitzer Straße 4601069 Dresden SUMMARY:Veenvliet: Building towards understanding — leveraging stem-cell- based embryo models to elucidate principles of development CLASS:PUBLIC DESCRIPTION:Speaker: Dr. Jesse Veenvliet\nInstitute of Speaker: Stembryogen esis Lab\, Max Planck Institute of Molecular Cell Biology and Genetics\, D resden\; Cluster of Excellence Physics of Life\, TU Dresden\; Center for S ystems Biology Dresden\nTopics:\nBiologie\, Chemie\, Informatik\, Medizin\ , Physik\, Willkommen\n Location:\n Name: TUD Andreas-Pfitzmann-Bau (http s://navigator.tu-dresden.de/karten/dresden/geb/n63)\n Street: Nöthnitzer Straße 46\n City: 01069 Dresden\n Phone: \n Fax: \nDescription:

Ou r lab investigates the principles underlying robust formation of the mamma lian body axes\, which organize the future body plan. While gene-regulato ry networks are well characterized\, how micro-environmental inputs arisin g from the physiological micro-environment contribute to the robustness of axial patterning and morphogenesis remains unclear. This is largely due t o the complexity and constraints of in vivo development. We use stem-cell- based embryo models\, such as gastruloids and trunk-like structures\, whic h combine scalability and ease of measurement and manipulation with in viv o-like patterning and morphogenesis\, making them ideal to obtain quantita tive\, causal\, mechanistic insights. We integrate embryo models with live imaging\, omics\, genetics\, biophysics\, and data science to uncover how interactions between the embryo model and its micro-environment drive rob ust morphogenesis.

Current research focuses on: (1) biophysical pri nciples of axis elongation\; (2) metabolic regulation of patterning and mo rphogenesis\; (3) roles of extracellular matrix remodeling\; (4) robustnes s in axial progenitor fate decisions\; and (5) leveraging variation to pre dict and control embryo model behavior.

Jesse Veenvliet studied Med icine at the Radboud University (Nijmegen)\, followed by an MSc in Experi mental &\; Clinical Neuroscience at Utrecht University. He then did his PhD in the field of molecular and developmental neuroscience in the lab o f Marten Smidt\, at the Rudolf Magnus Institute in Utrecht and the Swammer dam Institute of Life Sciences in Amsterdam. For his postdoc\, he joined t he lab of Bernhard Herrmann at the Max Planck Institute for Molecular Gene tics in Berlin\, where he developed one of the first stem-cell-based model s of early mammalian development. In May 2021 he moved to Dresden to start his independent lab at the Max Planck Institute of Molecular Cell Biology and Genetics. His group develops and uses mouse and human stem-cell-based embryo models to elucidate the principles governing robustness of mammali an body plan formation.

ONLINE BBB: Link ZIH-Collo quia (https://bbb.tu-dresden.de/b/har-oa6-col-lmy)

DTSTAMP:20260405T053509Z CREATED:20260312T063730Z LAST-MODIFIED:20260325T063536Z END:VEVENT END:VCALENDAR