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UID:DSC-22523
DTSTART;TZID=Europe/Berlin:20260507T110000
SEQUENCE:1778132311
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260507T120000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/22523
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Fletcher: The Architecture of Appetite: Physical Principles of Phag
 ocytic and Trogocytic Uptake
CLASS:PUBLIC
DESCRIPTION:Speaker: Daniel Fletcher\nInstitute of Speaker: UC Berkeley\, U
 SA\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Large Auditorium)\
 n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351
  210-0\n  Fax: +49 351 210-2000\nDescription: Cell-cell interactions are g
 overned by the complex and dynamic biophysical landscape of the cell surfa
 ce. For phagocytic cells like macrophages\, the decision to engulf a targe
 t is influenced by both the material properties and topography of the inte
 rface. We demonstrate that steric crowding of the glycocalyx acts as a phy
 sical barrier to antigen accessibility\, effectively lowering phagocytic e
 fficiency. We also find that target cortical stiffness serves as a mechani
 cal switch between whole-cell phagocytosis and trogocytosis (cellular \"ni
 bbling\"). This selective membrane extraction can reshape the molecular id
 entity of both cells through \"cross-dressing\,\" a poorly understood proc
 ess of membrane exchange. By integrating genome-scale CRISPR screens with 
 novel biophysical characterization tools\, we are investigating how the in
 terplay of surface crowding and target mechanics defines the appetite of i
 mmune cells\, offering new physical strategies to regulate immune function
  and guide other types of cell-cell interactions.
DTSTAMP:20260611T231454Z
CREATED:20251212T063829Z
LAST-MODIFIED:20260507T053831Z
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