How movement shapes life: the interplay between stickiness and motility in cancer invasiveness

Date

Jun 26, 2025

Time

3:00 PM - 4:30 PM

Speaker

Assoc. Prof. Josué Manik Nava-Sedeño

Affiliation

National Autonomous University of Mexico (UNAM)

Series

TUD ZIH Kolloquium

Language

en

Main Topic

Willkommen

Other Topics

Informatik, Mathematik, Medizin, Willkommen

Description

Tumors are classified as benign or malignant, depending on whether their cells are confined to the main tumor mass, or whether they are able to invade other tissues. It is generally assumed that tumor cells become malignant when they lose adhesive contacts with neighboring cells in a process called epithelial-mesenchymal transition. However, recent observations suggest that malignant tumor cells may retain adhesive properties while still performing long excursions into surrounding tissue. Using a mathematical model, it is shown that tumors can gradually become malignant purely by increasing the probability of long-distance cell movement, undergoing cyclic metastatic processes at high levels of adhesion and motility.

Josué Manik Nava-Sedeño is an associate professor at the National Autonomous University of Mexico (UNAM). He earned his PhD in Mathematics at TU Dresden, where he later worked as a postdoctoral researcher on statistical methods for medical decision-making. His research involves mathematical modeling of biological systems and cellular automata. He has taught numerous undergraduate and graduate courses, and has advised dozens of dissertations on modelling, dynamical systems, and stochastic processes.

Links

• Webseite
• Termindetails auf den Webseiten der TU Dresden (https://tu-dresden.de)

Last modified: Jun 26, 2025, 7:39:12 AM