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UID:DSC-21696
DTSTART;TZID=Europe/Berlin:20250211T100000
SEQUENCE:1739255730
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20250211T110000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/21696
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Schwayer: Cell heterogeneity and fate bistability drive tissue patt
 erning during intestinal regeneration
CLASS:PUBLIC
DESCRIPTION:Speaker: Cornelia Schwayer\nInstitute of Speaker: ETH Zürich |
  Dept. for Biosystems Science and Engineering (D-BSSE) &amp\; Friedrich Mi
 escher Institute for Biomedical Research (FMI)\, Basel\, Switzerland\nTopi
 cs:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Galleria II (VC))\n  Stree
 t: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\n
   Fax: +49 351 210-2000\nDescription: Tissue regeneration relies on the ab
 ility of cells to undergo de novopatterning. While tissue patterning has b
 een viewed as the transition from initially identical un-patterned cells t
 o an arrangement of different cell types\, recent evidence suggests that i
 nitial heterogeneities between cells modulate tissue-scale pattern formati
 on. Yet\, how such heterogeneities arise and\, thereafter\, regulate cell 
 type emergence in a population of cells is poorly understood. Using in viv
 o and in vitro mouseregenerative systems\, we identify a critical tissue d
 ensity that is required to induce heterogeneous inactivation of the mechan
 osensor YAP1. Experimental and biophysical approaches demonstrate that YAP
 1 cell-to-cell heterogeneity pre-patterns the first cell fate decision\, v
 ia both chromatin remodelling and a supracellular feedback between FOXA1 a
 nd Delta-Notch signalling. This feedback motif induces cell fate bistabili
 ty endowing memory to the system and the maintenance of patterns during ho
 meostasis. These findings reveal a generalisable framework in which transi
 ent cell-to-cell heterogeneity\, regulated by tissue-scale properties\, se
 rves as a critical control parameter for the emergence of cell fate and st
 able patterning during regeneration.
DTSTAMP:20260416T021236Z
CREATED:20250204T063747Z
LAST-MODIFIED:20250211T063530Z
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