From antifouling (nano-)coatings to smart biosensing in complex media

Date

May 22, 2024

Time

1:30 PM - 3:30 PM

Speaker

Hana Lísalová

Affiliation

Laboratory of Functional Biointerfaces, Czech Republic

Series

TUD nanoSeminar

Language

en

Main Topic

Physik

Other Topics

Physik

Host

Arezoo Dianat

Description

It is my honor to introduce our recent research on pushing the boundaries of antifouling bio-functional materials and nano-coatings, with a particular focus on enhancing biosensing in real-world media. To address this challenge, we explore the fascinating properties of ultrathin antifouling bio-functional polymer brushes. Namely, we will share recent advances in the following areas: i) design, fabrication, and responsive behavior of antifouling functionalizable brush nano-coatings, ii) molecular-level research on biofunctionalization, iii) the integration of zwitterionic brushes in advanced cell-on-a-chip systems, and iv) examples of antifouling point-of-care biosensors with tailor-made microfluidics systems. Results show how important (and challenging) it is to precisely control over the antifouling properties of polymer nano-coatings when submerged in real-world complex biological fluids. We detail new approaches to probe brushes with emerging electrochemical impedance spectroscopy technique. We present a new antifouling terpolymer brush with a superior combination of antifouling and bio-functionalization capabilities over similar bio-functional coatings. This material has been successfully employed in several antifouling biosensors; for example, in piezoelectric biosensors for the rapid sensitive detection of SARS-CoV-2 in complex clinical and surface swab samples as well as bacterial pathogens in fresh foods.

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Last modified: May 23, 2024, 7:39:29 AM