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UID:DSC-19994
DTSTART;VALUE=DATE:20230928
SEQUENCE:1688636505
TRANSP:OPAQUE
DTEND;VALUE=DATE:20231001
URL:https://www.dresden-science-calendar.de/calendar/en/detail/19994
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:EMBO Workshop: Epigenetics and Condensates in Lineage Decisions
CLASS:PUBLIC
DESCRIPTION:Speaker: \nInstitute of Speaker: \nTopics:\nWeiterbildung\nTime
 :\n11:00 AM-6:00 PM\n\n Location:\n  Name: TUD CRTD ()\n  Street: Fetscher
 straße 105\n  City: 01307 Dresden\n  Phone: +49 (0)351 458 82052\n  Fax: 
 +49 (0)351 458 82059 \nDescription: In metazoan development\, epigenetic m
 echanisms are required for the transition from multipotency to lineage com
 mitment. Epigenetic regulation contributes to the extraordinary reproducib
 ility and stability of multiple lineage decisions during gastrulation and 
 organogenesis. Recent evidence indicates that phase transitions in the nuc
 leus are involved in epigenetic mechanisms including the regulation of gen
 e expression and therefore\, potentially\, lineage decisions. The percepti
 on of nuclear proteins as structured folds with extra disordered regions t
 hat can be ignored has fundamentally shifted. Intrinsically disordered reg
 ions (IDRs)\, often together with nucleic acids\, are now thought to assem
 ble into condensates in the nucleus. Several nuclear condensates have been
  documented\, including the nucleolus\, and recently\, heterochromatin. Ev
 idence that condensates are involved in the regulation of gene expression 
 is also emerging. This EMBO Workshop is based on the anticipation that con
 densates in the nucleus will be involved in the regulation of gene express
 ion through epigenetic mechanisms. Conversely\, epigenetic mechanisms like
 ly include phase transitions to regulate gene expression. This EMBO Wworks
 hop aims to juxtapose the frontier of condensates and phase transitions wi
 th chromatin and the epigenetics of early developmental transcriptional de
 cisions in higher metazoans. We aim to catalyze interdisciplinary discussi
 on and speculations at the forefront of an emerging interface.  
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DTSTAMP:20260727T070232Z
CREATED:20230706T065608Z
LAST-MODIFIED:20230706T094145Z
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