Layered liquids – reaction chambers for chromatin ubiqutination
- Date
- Apr 20, 2023
- Time
- 11:00 AM - 12:00 PM
- Speaker
- Alwin Köhler
- Affiliation
- Max Perutz Labs Vienna, Austria
- Series
- MPI-CBG Thursday Seminar
- Language
- en
- Main Topic
- Biologie
- Host
- Dora Tang
- Description
- The conserved yeast E3 ubiquitin ligase Bre1 (human RNF20/40) and its partner, the E2 ubiquitin conjugating enzyme Rad6, monoubiquitinate histone H2B across gene bodies during the transcription cycle. Although processive ubiquitination might, in principle, arise from Bre1 and Rad6 travelling with RNA polymerase II, the mechanism of H2B ubiquitination across genic nucleosomes has remained unclear. We suggest that layered condensates of histone-modifying enzymes generate chromatin-associated ‘reaction chambers’, with augmented catalytic activity on gene bodies. I will present our recent progress on this topic integrating single-molecule with genome-wide studies of condensate behavior and functional genetic analyses.
Last modified: Apr 21, 2023, 7:35:16 AM
Location
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium)Pfotenhauerstraße10801307Dresden
- Phone
- +49 351 210-0
- Fax
- +49 351 210-2000
- MPI-CBG
- Homepage
- http://www.mpi-cbg.de
Organizer
Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
- Phone
- +49 351 210-0
- Fax
- +49 351 210-2000
- MPI-CBG
- Homepage
- http://www.mpi-cbg.de
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