Riboregulation: Biology, Mechanisms and Scope

Date

Oct 5, 2023

Time

11:00 AM - 12:00 PM

Speaker

Matthias W. Hentze

Affiliation

EMBL, Heidelberg, Germany

Series

MPI-CBG Thursday Seminar

Language

en

Main Topic

Biologie

Host

PhD students/Jonas Pöhls

Description

Until system-wide, unbiased analyses increased the number of recognized RNA-binding proteins (RBPs) well into the four-digit range, fewer than half of all RBPs were known (Castello et al., 2012; Hentze et al., 2018). This surprising outcome delivered new challenges for exploration: from the prevalence of structurally disordered RNA-binding regions with roles in the formation of RNA-protein condensates (Castello et al., 2016) to unsuspected and potentially pervasive connections between intermediary metabolism and RNA regulation (Beckmann et al., 2015). Riboregulation, the direct control of protein function by RNA, has begun to emerge as a new paradigm of biological control (Horos et al., 2019; Huppertz et al., 2022). We are beginning to understand molecular mechanisms of riboregulation, and investigation of the RBPs of mouse organs points to their broad roles in mammalian physiology (Perez-Perri et al., 2023). I will discuss these new facets of the RBP World and their implications for cell biology, metabolism and disease mechanisms.

Last modified: Oct 6, 2023, 7:38:22 AM