Bi

Inspecting the secretory pathway with whole-cell, volumetric FIB-SEM

Date
Sep 20, 2021
Time
4:00 PM - 5:00 PM
Speaker
Jennifer Lippincott-Schwartz
Affiliation
Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, USA
Language
en
Main Topic
Biologie
Host
Rita Mateus
Description
Inside of a cell, snaking membranes comprising the ER synthesize up to 30% of the proteins encoded for by the genome. Many of these newly minted proteins only function after being exported from the ER to other cellular destinations. This occurs at sites distributed across the ER called ER exit sites (ERESs). Here, we provide a fresh look at ERESs and the secretory pathway using different imaging technologies, including whole-cell volumetric FIB-SEM. Rather than vesicles alone, the ER spawns an elaborate, interwoven tubular network of contiguous lipid bilayers (ER exit site) for protein export. This receptacle is capable of extending microns along microtubules while still connected to the ER by a thin neck. COPII localizes to this neck region and dynamically regulates cargo entry from the ER, while COPI acts more distally, escorting the detached, accelerating tubular entity on its way to joining the Golgi apparatus through microtubule-directed movement.

Last modified: Sep 21, 2021, 12:06:45 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (Zoom)Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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