Bi

Growth and Scaling in Zebrafish Fins

Date
Jun 17, 2021
Time
11:00 AM - 12:00 PM
Speaker
Rita Mateus
Affiliation
MPI-CBG Dresden
Series
MPI-CBG Thursday Seminar
Language
en
Main Topic
Biologie
Host
Anne Grapin-Botton
Description
Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning. For some morphogens, adaptation of the gradients to tissue size allows morphological patterns to remain proportioned as the organs grow. In the zebrafish pectoral fin, we found that BMP signalling forms a two‑dimensional gradient. The length of the gradient scales with tissue length and its amplitude increases with fin size according to a power-law. Gradient scaling and amplitude power‑laws are signatures of growth control by time derivatives of morphogenetic signalling: cell division correlates with the fold change over time of the cellular signalling levels. We show that Smoc1 regulates BMP gradient scaling and growth in the fin. Smoc1 scales the gradient by means of a feedback loop: Smoc1 is a BMP agonist and BMP signalling represses Smoc1 expression. Our work uncovers a novel layer of morphogen regulation during vertebrate appendage development.

Last modified: Jun 18, 2021, 12:08:42 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (Zoom online)Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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