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UID:DSC-17250
DTSTART;TZID=Europe/Berlin:20200423T170000
SEQUENCE:1587376066
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20200423T173000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/17250
LOCATION:TUD Falkenbrunnen\,  01187 Dresden
SUMMARY:Fabel: (f)MRI and neuropsychological assessments of neuronal plasti
 city in younger and older professional musicians
CLASS:PUBLIC
DESCRIPTION:Speaker: Dr. Klaus Fabel\, Dr. Miranka Wirth & Dr. Theresa Köb
 e\nInstitute of Speaker: DZNE\, https://www.dzne.de/ueber-uns/standorte/dr
 esden/\nTopics:\n\n Location:\n  Name: TUD Falkenbrunnen ()\n  Street:  \n
   City: 01187 Dresden\n  Phone: \n  Fax: \nDescription: Background: The DZ
 NE Dresden focuses on plasticity processes in the adult and ageing brain a
 nd investigates\, how plasticity determines the brain’s ability to compe
 nsate for degeneration. We are interested in professional musicians since 
 musical training increases brain plasticity both on a morphological and fu
 nctional level in various brain regions\, including the hippocampus\, and 
 is suggested to be a protective lifestyle factor in the prevention of deme
 ntia.     History of our project: The hippocampus plays a major role in sp
 atial learning and navigation. In an initial behavioral study\, we used an
  adaption of the Morris water maze task (DSNT) and tested for a difference
  in spatial memory between musicians (students of the HfM Dresden) compare
 d to control students (non-musicians). In neuropsychological assessments\,
  musicians had better short-term memory and mental flexibility with no dif
 ferences in visual\, verbal or overall long-term memory. The DSNT showed s
 horter path lengths to the platform (navigation target) in musicians with 
 similar or longer latency times\, suggesting that long-term musical traini
 ng might alter strategies of how hippocampus-dependent spatial information
  is used.    In order to investigate hippocampal activation using fMRI\, w
 e conducted a first pilot using the DSNT in 2018. Unfortunately\, the DSNT
  was not entirely adapted for this application\, thus fMRI data analysis w
 as cumbersome and reprogramming of the task is needed. Since this will req
 uire time and hippocampal activation in musicians is a major objective of 
 our study\, we want to compare two well-established and validated fMRI tas
 ks\, the Memory Encoding task (FADE\, Düzel 2011 & 2018) and the Memnonic
  discrimination task (Berron 2019 & Maass 2019) in a second pilot (pilot 2
 ). Our aim is: to select one fMRI tasks showing better/more reliable activ
 ation of the hippocampus/memory network in younger and older adults. Pilot
  2 will include 10 young (18-30y) and 10 older adults (55-65y) in total.  
    Main study: Our major aim is to determine\, if lifelong musical trainin
 g prevents decline in cognitive abilities and brain integrity (measured us
 ing MRI). The main study will include a max. of 128 probands (see below). 
 The MRI protocol will e.g.\, include functional MRI (as determined in pilo
 t 2)\, high resolution T2 for hippocampus volumetry (ASHS analysis)\, and 
 DTI (CSD-analysis\, ExploreDTI) for the assessment of white matter tracts\
 , e.g. the fornix as the major output of the hippocampus. The overall proj
 ect (protocol for MRI and neuropsychological assessments) will serve as a 
 platform for future intervention studies using lifestyle-based interventio
 ns e.g.\, dancing in older adults with increased risk for Alzheimer’s di
 sease.
DTSTAMP:20260730T033434Z
CREATED:20200420T094746Z
LAST-MODIFIED:20200420T094746Z
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