Bi

CMCB Life Sciences Seminar: Protein Sequence Space

Date
Feb 27, 2020
Time
1:00 PM - 2:00 PM
Speaker
Agnes Troth-Petroczy
Affiliation
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and Center for Systems Biology Dresden (CSBD)
Series
CMCB Life Sciences Seminar
Language
en
Main Topic
Biologie
Other Topics
Biologie
Host
James Saenz (B CUBE)
Description

Publications:



1.       Toth-Petroczy A*, Palmedo P*, John Ingraham JI, Thomas A. Hopf TA, Berger B, Sander C, Marks DS. Structured states of disordered proteins from genomic sequences. Cell 2016, 167(1):158-70.



2.       Rockah-Shmuel L, Toth-Petroczy A, Sela A, Wurtzel O, Sorek R and Tawfik DS. The Occurrence and Bypass of Frame-shifting Insertion-Deletions (InDels) to give Functional Proteins are correlated. PloS Genetics 2013 (10) e1003882



3.       Dellus-Gur E*, Toth-Petroczy A*, Elias M, Tawfik DS. What makes a protein fold amenable to functional innovations? Fold polarity and stability trade-offs. J Mol Biol 2013; 425(14):2609-21.



4.       Toth-Petroczy A and Tawfik DS. Protein insertions and deletions enabled by neutral roaming in sequence space. Mol Biol Evol 2013; 30(4):761-71.



5.       Tóth-Petróczy A and Tawfik DS. Slow protein evolutionary rates are dictated by surface-core association. PNAS 2011, 108(27):11151-6.



Abstract:



Protein sequence space is vast, the possibilities are astronomical, yet only a tiny fraction of it is sampled by existing proteins. We mine evolutionary information from millions of genomes to understand how protein families evolve, and what rules govern their functional and structural divergence. We focus not only on genetic mutations but also on phenotypic mutations, i.e. mutations introduced by transcriptional and translational machinery. We wish to answer how proteins remain robust to mutations and facilitate innovations at the same time. We combine bioinformatics, modelling and experimental evolution to answer fundamental questions about molecular evolution.



Everybody is very welcome!

Links

Last modified: Feb 27, 2020, 12:07:24 AM

Location

Center for Regenerative Therapies Dresden (CRTD, ground floor, auditorium left)Fetscherstraße10501307Dresden
Phone
+49 (0)351 458 82064
Fax
+49 (0)351 458 82059
E-Mail
TUD CRTD
Homepage
http://www.crt-dresden.de

Organizer

Center for Molecular and Cellular Bioengineering (CMCB)01062Dresden
Phone
+49 351 463-40359
Fax
+49 351 463-40322
E-Mail
TUD CMCB
Homepage
https://tu-dresden.de/cmcb
Scan this code with your smartphone and get directly this event in your calendar. Increase the image size by clicking on the QR-Code if you have problems to scan it.
  • BiBiology
  • ChChemistry
  • CiCivil Eng., Architecture
  • CoComputer Science
  • EcEconomics
  • ElElectrical and Computer Eng.
  • EnEnvironmental Sciences
  • LaLaw
  • CuLinguistics, Literature and Culture
  • MtMaterials
  • MaMathematics
  • McMechanical Engineering
  • MeMedicine
  • PhPhysics
  • PsPsychology
  • SoSociety, Philosophy, Education
  • SpSpin-off/Transfer
  • TrTraffic
  • TgTraining
  • WlWelcome