Influence of natural and synthetic nanomaterials on bone regeneration
- Dec 13, 2019
- 1:00 PM - 2:00 PM
- Prof.Dr. Barbara Kaltschmidt
- Department of Cell Biology, Faculty of Biology,University of Bielefeld
- Main Topic
- Kristina Krummer
- Bone regeneration is a highly orchestrated process crucial for endogenous healing procedures after accidents, infections or tumor therapy.
Changes in surface nanotopography are known to directly affect the formation of osteogenic cell types, although no direct linkage to the endogenous nanotopography of bone was described so far. I will present the presence of pores of 31.93 ± 0.97 nm diameter on the surface of collagen type I fibers, the organic component of bone, and demonstrate these pores to be sufficient to induce osteogenic differentiation of several adult human stem cell types. SiO2 nanoparticles, biomimicing 31.93 ± 0.97 nm pores, were able to induce osteogenic differentiation of stem cells in vitro also.
In addition I will show the regenerative potential of several nanomaterials to drive calvarial bone regeneration in vivo in a cell-and growth factor free manner.
Last modified: Dec 6, 2019, 12:05:30 AM
Leibniz Institut für Festkörper- und Werkstoffforschung Dresden (D2E.27, IIN)Helmholtzstraße2001069Dresden
Leibniz Institut für Festkörper- und Werkstoffforschung DresdenHelmholtzstraße2001069Dresden
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