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CMCB Life Sciences Seminar: Molecular, mechanical, and cellular mechanisms of fibrosis

Date
Mar 19, 2020
Time
1:00 PM - 2:00 PM
Speaker
Boris Hinz
Affiliation
University of Toronto
Series
CMCB Life Sciences Seminar
Language
en
Main Topic
Willkommen
Other Topics
Willkommen
Host
Elisabeth Fischer-Friedrich
Description

Hinz, B. and Lagares, D., (2020) Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases. Nature Reviews Rheumatology 16(1):11-31



Pakshir, P., Alizadehgiashi, M., Wong, B., Coelho, N.M., Chen, X., Gong, Z., Shenoy, V.B., McCulloch, C., and Hinz, B. (2019): Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix. Nature Communications 10: 1850



Li, C.X., Talele, N.P., Boo, S., Knee-Walden, E., Koehler, A., Kapus, A., Speight, P., Balestrini, J.L., Hinz, B. (2017). Micro RNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells. Nature Materials 16(3):379-389



Klingberg, F., Chow, M. L., Koehler, A., Boo, S., Buscemi, L., Quinn, T. M., Costell, M., Alman, B. A., Genot, E., and Hinz, B. (2014). Prestress in the extracellular matrix sensitizes latent TGF-beta1 for activation. J Cell Biol 207, 283-297



Buscemi, L., Ramonet, D., Klingberg, F., Formey, A., Smith-Clerc, J., Meister, J.-J., and Hinz, B.: (2011) The single-molecule mechanics of the latent TGFβ1 complex. Current Biology 21, 2046–2054



Abstract:



To rapidly restore mechanical integrity of tissues after injury, a variety of different cell types are activated to become myofibroblasts. Hallmarks of the myofibroblast are secretion of extracellular matrix (ECM), development of adhesion structures with the ECM, and formation of contractile stress fiber bundles. When contracture and ECM remodeling become progressive and manifest as organ fibrosis, stiff scar tissue obstructs and ultimately destroys organ function. Pivotal for the formation and persistence of myofibroblasts are mechanical stimuli arising during tissue repair and chronic persistence of inflammatory cells. I will give an overview on our current projects that address how mechanical factors orchestrate the development of myofibroblasts by mediating direct and far/ranging communication between myofibroblasts and macrophages. By understanding and manipulating myofibroblast and macrophage mechanoperception we will be able to devise better therapies to reduce scarring and support normal wound healing.

Links

Last modified: Feb 25, 2020, 12:09:41 AM

Location

Center for Regenerative Therapies Dresden (CRTD, ground floor, auditorium left)Fetscherstraße10501307Dresden
Phone
+49 (0)351 458 82064
Fax
+49 (0)351 458 82059
E-Mail
TUD CRTD
Homepage
http://www.crt-dresden.de

Organizer

Center for Molecular and Cellular Bioengineering (CMCB)01062Dresden
Phone
+49 351 463-40359
Fax
+49 351 463-40322
E-Mail
TUD CMCB
Homepage
https://tu-dresden.de/cmcb
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