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Common and Distinct Mechanisms of Social Anxiety and Alcohol Use (MOSAIC)

Date
Nov 14, 2019
Time
5:00 PM - 5:30 PM
Speaker
Prof. Tanja Endrass, M. Sc. Verena Wüllhorst
Affiliation
TU Dresden
Series
TUD NIC Kolloquium
Language
en
Main Topic
Psychologie
Description
Social anxiety disorder (SAD) co-occurs frequently with alcohol use disorder (AUD). Our project aims to
disentangle common and specific behavioral and neuronal mechanisms of SAD and AUD to investigate
potential shared vulnerabilities. Whereas SAD is associated with increased threat reactivity and
performance monitoring, the risk to develop AUD is suggested to be enhanced under either altered threat
reactivity or reward sensitivity and impulsivity. However, it remains unclear which combination of
alterations in these mechanisms are associated with the comorbidity of SAD and AUD. Prior work
suggests that there is an impulsive-anxious subtype among individuals with SAD which might account for
problematic alcohol use and is associated with self-reported reward sensitivity and impulsivity. However,
no study to date has investigated underlying mechanisms regarding this comorbidity. We will focus on
markers robustly associated with anxiety or addiction. Threat reactivity will be assessed as startle
response using electromyography in a no/predictable/unpredictable threat task. Markers for reward
sensitivity will be striatal activity and reaction times in a monetary incentive delay task during functional
magnetic resonance imaging. The error-related negativity will serve as a marker for performance
monitoring and will be assessed in a flanker task using electroencephalography (EEG). Impulsivity will be
examined with response inhibition and delay discounting. The N2 and P3 amplitude will serve as neuronal
markers of response inhibition in a stop signal task during EEG. The discounting factor (k-value) will serve
as a behavioral marker assessed in a delay discounting task. This multimethod study will be conducted in
four groups of participants: Individuals with SAD, AUD, comorbid SAD + AUD and healthy controls.
Besides dimensional and group comparison analyses for each mechanisms, we will conduct an overall
latent class analysis to examine whether underlying behavioral and neuronal mechanisms explain across
and beyond diagnoses the comorbidity of SAD and AUD. The results of this project would be highly
relevant for understanding the comorbidity between the examined disorders and providing a basis for
developing and improving tailored treatment procedures for individuals with SAD and AUD.
Links

Last modified: Nov 8, 2019, 1:12:44 PM

Location

TUD Falkenbrunnen (FAL 156, Chemnitzer Str. 46b)01187Dresden

Organizer

Neuroimaging CentreChemnitzer Str.46a01187Dresden
Phone
+49 351 463 42063
Fax
+49 351 463 42438
E-Mail
NIC
Homepage
http://www.nic-tud.de
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