Bi

Two mechanisms of chromosome folding

Date
Oct 22, 2020
Time
4:00 PM - 5:00 PM
Speaker
Leonid Mirny
Affiliation
Massachusetts Institute of Technology, Cambridge, USA
Language
en
Main Topic
Biologie
Host
Jan Brugues
Description
Hi-C technique and microscopy together provide a comprehensive picture of spatial chromosome organization. Recent experiments and polymer modeling suggested two major mechanisms of chromosome organization. The first mechanism is the active (ATP-dependent) process of loop extrusion by SMC complexes, that is responsible for formation of domains during interphase, and chromosome compaction and segregation in metaphase. The second mechanism is the spatial compartmentalization of the genome, which we found to be mediated by affinity between heterochromatic regions. I will also discuss how loop extrusion can function as a mediator of long-range communication between genomic elements.

Last modified: Oct 23, 2020, 12:08:59 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium)Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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