Two mechanisms of chromosome folding
- Date
- Oct 22, 2020
- Time
- 4:00 PM - 5:00 PM
- Speaker
- Leonid Mirny
- Affiliation
- Massachusetts Institute of Technology, Cambridge, USA
- Language
- en
- Main Topic
- Biologie
- Host
- Jan Brugues
- Description
- Hi-C technique and microscopy together provide a comprehensive picture of spatial chromosome organization. Recent experiments and polymer modeling suggested two major mechanisms of chromosome organization. The first mechanism is the active (ATP-dependent) process of loop extrusion by SMC complexes, that is responsible for formation of domains during interphase, and chromosome compaction and segregation in metaphase. The second mechanism is the spatial compartmentalization of the genome, which we found to be mediated by affinity between heterochromatic regions. I will also discuss how loop extrusion can function as a mediator of long-range communication between genomic elements.
Last modified: Oct 23, 2020, 12:08:59 AM
Location
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium)Pfotenhauerstraße10801307Dresden
- Phone
- +49 351 210-0
- Fax
- +49 351 210-2000
- MPI-CBG
- Homepage
- http://www.mpi-cbg.de
Organizer
Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
- Phone
- +49 351 210-0
- Fax
- +49 351 210-2000
- MPI-CBG
- Homepage
- http://www.mpi-cbg.de
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