CMCB Life Sciences Seminar: Piconewton-sensitive biosensors to investigate adhesion mechanics in cells
- Date
- Oct 24, 2019
- Time
- 4:00 PM - 5:00 PM
- Speaker
- Prof. Carsten Grashoff
- Affiliation
- University of Münster
- Series
- CMCB Life Sciences Seminar
- Language
- en
- Main Topic
- Biologie
- Other Topics
- Medizin, Biologie
- Host
- Dr. Gokul Kesavan (CRTD)
- Description
To investigate the molecular mechanisms underlying cell adhesion mechanics, we developed a set of single-molecule‒calibrated biosensors that are sensitive to physiologically relevant forces in the low piconewton range. These biosensors are genetically encoded and can be utilized to determine molecular forces acting across individual molecules in cells. In my seminar, I will describe how their application to the focal adhesion protein talin and the desmosomal molecule desmoplakin revealed fundamental differences in how distinct adhesion molecules modulate intracellular force transduction.
- Links
Last modified: Oct 24, 2019, 12:10:04 AM
Location
Center for Regenerative Therapies Dresden (2nd floor, seminar rooms 1 and 2)Fetscherstraße10501307Dresden
- Phone
- +49 (0)351 458 82052
- Fax
- +49 (0)351 458 82059
- TUD CRTD
- Homepage
- https://tu-dresden.de/cmcb/crtd
Organizer
Andere Einrichtungen der TU Dresden, c/o Dezernat Forschungsförderung und TransferWeißbachstr.701062Dresden
- Phone
- +49 351 463-32583
- Fax
- +49 351 463-37802
- TUD Andere
- Homepage
- http://www.tu-dresden.de
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