BiMe

Piconewton-sensitive biosensors to investigate adhesion mechanics in cells

Date
Oct 24, 2019
Time
4:00 PM - 5:00 PM
Speaker
Prof. Carsten Grashoff
Affiliation
University of Münster
Series
CMCB Life Sciences Seminar
Language
en
Main Topic
Biologie
Other Topics
Biologie, Medizin
Host
Dr. Gokul Kesavan (CRTD)
Description
AbstractTo investigate the molecular mechanisms underlying cell adhesion mechanics, we developed a set of single-molecule‒calibrated biosensors that are sensitive to physiologically relevant forces in the low piconewton range. These biosensors are genetically encoded and can be utilized to determine molecular forces acting across individual molecules in cells. In my seminar, I will describe how their application to the focal adhesion protein talin and the desmosomal molecule desmoplakin revealed fundamental differences in how distinct adhesion molecules modulate intracellular force transduction.
5 most important publications 1. Price AJ, Cost AL, Ungewiβ H, Waschke J, Dunn AR, and Grashoff C. 2018. Nat Commun 11; 9:5284.2. Ringer, P. Weißl, A., Cost, A.L., Freikamp, A., Sabass, B., Mehlich, A., Tramier, M., Rief, M. and Grashoff, C. 2017. Nat Methods 14: 1090-1096. 3. Austen KA, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, and Grashoff C. 2015. Nat Cell Biol 17: 1597-1606.4. Hoffman BD, Grashoff C, and Schwartz MA. 2011. Nature 475(7356): 316-323.5. Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, and Schwartz MA. 2010. Nature 466(7303): 263-266.Everybody is very welcome!
Links

Last modified: Oct 22, 2019, 12:05:31 AM

Location

DFG Center for Regenerative Therapies Dresden (CRTD, ground floor, auditorium left)Fetscherstraße10501307Dresden
Phone
+49 (0)351 458 82064
Fax
+49 (0)351 458 82059
E-Mail
CRTD
Homepage
http://www.crt-dresden.de

Organizer

DFG Center for Regenerative Therapies DresdenFetscherstraße 10501307Dresden
Phone
+49 (0)351 458 82064
Fax
+49 (0)351 458 82059
E-Mail
CRTD
Homepage
http://www.crt-dresden.de
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