Bi

Lipids and light for studying (β-)cell biology

Date
Mar 5, 2020
Time
11:00 AM - 12:00 PM
Speaker
Carsten Schultz
Affiliation
Oregon Health & Science University, Portland, USA
Series
MPI-CBG Thursday Seminar
Language
en
Main Topic
Biologie
Host
André Nadler
Description
Our lab is interested in studying the signal transduction network underlying insulin secretion. We are particularly interested in better understanding the role of lipids in this respect. For this purpose, we are preparing novel lipid-based tools in the chemistry lab. I will present the recently published caged version of the cannabinoid 2-AG and its use in investigating calcium oscillations in β-cells. I will further inform about unpublished work on multifunctional lipid derivatives that are useful for identifying new lipid-binding proteins. On the cell biology side, we find that apart from insulin β-cells secret a large number of small molecules that seem to be essential for synchronized insulin secretion. Finally, I will introduce thermogenetics as a non-invasive tool to generate calcium oscillations and insulin secretion in β-cells.

Last modified: Mar 6, 2020, 12:09:26 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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