BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-16075
DTSTART;TZID=Europe/Berlin:20190522T110000
SEQUENCE:1561382541
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20190522T120000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/16075
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Doyle: Decoding How Cells Use Molecular Networks to Interpret Physi
 cal Cues
CLASS:PUBLIC
DESCRIPTION:Speaker: Prof. Adele Doyle\nInstitute of Speaker: University of
  California\, Santa Barbara\, Center for BioEngineering\nTopics:\nBiologie
 \, Medizin\n Location:\n  Name: TUD CRTD (CRTD\, 2nd floor\, seminar rooms
  1 & 2)\n  Street: Fetscherstraße 105\n  City: 01307 Dresden\n  Phone: +4
 9 (0)351 458 82052\n  Fax: +49 (0)351 458 82059 \nDescription: AbstractCel
 ls are computational units that must constantly make important decisions\,
  such as whether to divide\, grow\, move\, or specialize\, to maintain tis
 sues and organs in a healthy state. Both biochemical and physical inputs a
 re processed in cells through molecular codes that control the cell's deci
 sions and specify the output cellular behaviors. The decision of a cell to
  specialize into a distinct cell type (differentiation) requires the cell 
 to modify its ability to sense and respond to input physical cues (e.g.\, 
 mechanical forces and electrical cues). These physical inputs cause change
 s in gene expression and cell function that are essential for embryonic de
 velopment and adult organ function. Disruption of this response disrupts t
 he normal tissue state and\, in many cases\, leads to disease states. Desp
 ite the physiologic importance of cell differentiation\, the architecture 
 and behavior of the molecular networks encoding how single cells sense and
  respond to physical cues remain unclear. In this talk\, I will describe w
 ork to decode the molecular networks in the cardiovascular and nervous sys
 tems. We established the architecture and function of a molecular network 
 for sensing vascular-relevant shear stress\, developed a new experimental 
 method called FRISCR (Fixed and Recovered Intact Single-cell RNA) that imp
 roves signal quality and detection sensitivity of high-throughput RNA meas
 urements by two orders of magnitude\, and developed a new computational me
 thod to determine molecular network identity and dynamics during electrica
 l specialization of neurons. I will also highlight related future opportun
 ities for applying engineering insights to study of biological systems.
DTSTAMP:20260805T053148Z
CREATED:20190515T220759Z
LAST-MODIFIED:20190624T132221Z
END:VEVENT
END:VCALENDAR