RNA Biology and its link to human diseases

Date

Mar 28, 2019

Time

4:00 PM - 5:00 PM

Speaker

Prof. Utz Fischer

Affiliation

University of Würzburg, Biocenter

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Prof. Rolf Jessberger (Institute of Physiological Chemistry)

Description

AbstractThe generation of messenger RNAs (mRNAs) and their translation into proteins depends on the elaborate interplay of a numerous trans-acting factors. These factors are often organized in macromolecular machines, which enable all steps in mRNA metabolism and timely coordinate their progression. The Fischer group studies the functional dynamics of key macromolecular machines acting on RNA using a combination of biochemical, structural and systems biology approaches. RNA-related pathways have been linked to a broad spectrum of human diseases. By combining basic RNA research with biomedical approaches we investigate how these pathways and networks are changed in different disease settings. PapersImpaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation AB Prusty, R Meduri, BK Prusty, J Vanselow, A Schlosser, U Fischer J Cell Biol 216 (8), 2391-2407 (2017) Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization Neuenkrichen, N., Englbrecht, C., Ohmer, J., Ziegenhals, T., Chari, A., and Fischer, U. EMBO Journal 34(14):1925-41 (2015) Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Stoll G, et al., Nature Neuroscience 16: 1228-1237 (2013) Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2 Dill H, Linder B, Fehr A, Fischer U Genes & Development 26(1):25-30 (2012) An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs Chari A, Golas M, Neuenkirchen N, Klingenhäger M, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U Cell 135:497-509 (2008)

Links

• to announcement of the organizer

Last modified: Mar 28, 2019, 1:08:56 AM